World Congress on Polycystic Ovarian Syndrome and Fertility December 17- 18 2018 Abu Dhabi, UAE

Fertility can be influenced with a Polycystic ovarian disorder, when it is caused by variables like an abundance generation of androgens called male hormones, Affront levels alongside irritation causes anovulation.  Anovulation is a process of inability to release an oocyte due to irregular menstrual cycles. This obstacles caused by inconsistency of monthly cycle can cause menopause to a women beneath control and women enduring from PCOS, in case this handle of disturbance in ovulation proceeds it’s difficult to end up pregnant for women which can cause trouble in getting pregnancy which may lead complication to induce pregnantly and most of the hormones ended up uneven comes about in making difficult to carry a child.​

Endometrial Cancer is a  type of cancer begins within the ovaries which are sized of almond that which involves in producing of eggs. Endometrial cancer arises from the endometrial layer (the lining of the uterus/womb). This is caused by the abnormal growth of the cells that which have a capability to spread and invade the normal cells and functioning of the other systems. Sometimes it is also referred to as uterine cancer. This is the type of cancer in which relatively known as Endometrioid carcinoma. The main symptom of this cancer is vaginal bleeding which is not associated with the menstrual cycle, and this endometrial cancer often mostly occurs after menopause. We can also consider that the cancer is caused by the excess exposure of uterine walls to the estrogen levels. While considering the cause of this cancer 2-5% cases are related to the genes inherited from the parents. Prolonged menstrual cycles more than 35 days may become severe condition which leads patient to endometriosis. Excess intake of red meat can lead to endometrial so, less red meat can protect women from the stage of endometrial cancer.

The women who are dealing with the polycystic ovarian syndrome have side effects like Diabetes, Obesity, Obstructive sleep apnea, Heart diseases, Mood disorders and Endometrial cancer will be the cause of ovarian syndrome to women having  premenopausal /postmenopausal, the major function in blood varies is that the insulin resistance  gets developed an increase in blood glucose levels in the body this can be known by conducting the blood tests of insulin levels. Excess blood Glucose leads to the bookmark of TYPE-2 diabetes in patients. PCOS is the most common hormonal disorder in women with childbearing and can lead to issues with infertility, do these reasons the women who are suffering from weight loss or weight gain. The women who are more sensitive to insulin or resistance to insulin which was caused by the hormonal imbalance are more promptly prone to the obese or overweight that which keeps the patient at higher risk of heart diseases, sleep apnea, and uterine cancer.  The obstructive sleep apnea is associated with the metabolic disorders of the of the insulin that which caused by the intolerance of the glucose levels in bloodstream, the main symptom of OSA is restricted sleep altogether during the night times, the early stages of this OSA is snoring at the night times and have irregular sleep, and that can cause effects of the quality of sleep towards the patient associated with the PCOS. No such women suffering from PCOS will experience the same symptoms the condition of women with PCOS has several disorders which are occurred due to the polycystic ovarian disorder/syndrome, PCOS is not just related with the endocrinological  disorders it is also associated with emotional and mental conditions like Anxiety depression, difficulty in concentrating, fatigue, mood swings and chronic stress. Zinc plays a vital role in building immunity for women suffering from PCOS that results in infertility and also involves in improvement of fertility.

In vitro fertilization can be depicted as a helped regenerative innovation or restorative treatment for a woman to conceive. In vitro fertilization took a step to require portion within the strategy of checking and stimulating women’s ovulatory Handle by extraction of sperm test from father and egg from mother and letting them combine and permitted for fertilization to make an fetus. Once the formation of embryo completed this newly formed embryo will be implanted into the mother’s uterus this implantation causes women to get conceive easily because the eggs have been fertilized by sperms outside the normal biological process. It is also a called as a type of assisted reproductive technology in which mostly used for the treatment of infertility treatment. Couples encountering fertility treatment may advantage from genetic screening and supplementation with 5-MTHF glucosamine salt instead of excessive measurements of folic acid destructive generally utilized

High levels of male sex hormones (Androgens) and irregularity in the production of sugar levels in the bloodstream causes insulin resistance can adversely affect menstrual cycle and prevent the release of an egg on a regular basis and can even stop completely or irregularly. This condition makes more difficult for women suffering from polycystic ovarian syndrome to have their easy pregnancy and it is more difficult for those women to conceive, sometimes it can lead to miscarriage. Women in some criteria may also experience reduced fertility or sub-fertility which requires further medical assistance. 60% of women suffering from PCOS become pregnant without any medical assistance

Laparoscopy is an advanced surgical procedure in which insertion of a fiber- optic instrument in the abdomen through the abdominal wall to have a clear internal view of organs. Laparoscopy is one of the most advanced techniques referred to the patients suffering from infertility, it is used to treat or diagnose the fertility complications or factors causing fertility problems. Laparoscopy can be performed to the patients who are previously known to a basic evaluation of infertility include ultrasound, ovarian reserve for female and semen analysis for men. Laparoscopy involves in the indepth examination of the uterus, ovaries, fallopian tubes and pelvis of women having fertility complications which results out to know the abnormalities that might involve women fertility or inability to conceive. If this detects the complication or abnormalities during laparoscopy additional instruments can be placed through a tiny incision which can involve in the diagnosis of infertility problems like Poor ovarian Reserve or Ovarian Failure.

Fertilization is the process of combining male gamete and female gamete which results in the formation of zygote.ome in ten percent of male suffering from infertility with spermatogenesis disorder due to drastic alteration in their lifestyle, surroundings or environmental factors and hormonal imbalances most of the couple i.e., 17.2% couple in 30% are not supposed to have a child. There are numerous reasons to evaluate that causing infertility either in male or female of that certain couple. To get fertile various modern inventive techniques has been introduced. Since these methods are based on the steps or procedure of in vitro improvement in semen quality to over the natural barrier of fertilization. Techniques include various process on their own specific indications.

Immune infertility has become a severe health issue involving 1 in 5 women under normal conditions; moreover, women with the polycystic ovarian syndrome has become very frequent. Semen that is known as the composite fluid which contains sperm, cellular vesicles, and other cell components, this semen could be a reason for sensitization of female genital tract. Natural tolerance of female regenerative tract by immune rejection of male semen which is a prior factor leading to local or systemic response. Iso-immunization is also associated with infertility. Numerous specific components of the regenerative system which do not represent in other body systems those many of are immunogenic efforts. The major advantage involved in the immunological approach of fertility is very effective or potential for women who are infrequent administration by a specialist's trained people who could deliver antifertility services. Anti-sperm antibodies

Most of the women suffering from Polycystic Ovarian Syndrome have a direct effect on nearer or inter related major organs which is usually caused by Hyperinsulinemia, this hyperinsulinemia will adversely affect's major organs. in order of increase in regular alterations of PCOS in women it leads to various disadvantages to the major functioning organs due to increased levels of androgen hormones in the body that which influencing the higher risk factor to the patient and leads patient to the severe condition in which it leads to the patient medical profiles with various diseases that cause side effects to the other organs in the system. Women at this condition may experience severe complications in feeding babies after giving birth due to decreased levels of estrogen that which is the major factor which obstructs by making less estrogen into mammary tissue building. Some of the major factors that evolve autism in a child of a mother suffering from Polycystic Ovarian Syndrome. Women who are prone to PCOS may have several neuronal defects which can cause psychiatric disorders in the stage of pre or postnatal span. These psychiatric impediments in women with PCOS are often related to irregularities in menstrual cycles.

Fertility of women adversely affected by the hormonal and endocrine-metabolic disorder called polycystic ovarian syndrome is a heterogeneous hormonal imbalance is the condition in which characterized by the hirsutism, hyperandrogenism and various other conditins primarily show an effect on the female reproductive system that in turn causes infertile nature of women regenerative hormones. PCOS has no course it can be treated in early condition and symptoms like hirsutism, acne, obesity and other involved in specific treatment. Fertility is indigenously related to subsequent alterations in lifestyle changes like exercising and maintaining the dietary subsidies and medication to improve the problem of infertility Thinkiing to achieve fertility of such women suffering from PCOS is little more difficult there are some medications and treatments which show varied results. 

The richness of fertility in women can be characterized as the women have hormonal cycles that which decide when they can accomplish pregnancy, the capability of women to create a sibling called fertility. Fertility decreases in arrange with age movement in both men and women. A woman, for the most part, has a high rate of losing fertility around the age of 45-50. which can be measured through fertility (Potential for generation). Infertility basically alludes to the failure of women to deliver or conceive a child after 12 months or feeling trouble to induce a pregnancy to full term. There are no such positive components to assess the cause of infertility it depends on the hormonal imbalances but the most indication of infertility incorporates, failure to induce pregnant, sporadic menstrual cycles, hormonal complications such as hair development, sexual work. Components causing infertility incorporate. women enduring from a unsuccessful labor, stillbirth have a major impact on their richness wellbeing subsequently undiscovered coeliac infection may also lead to women to experience difficulty in conceiving, having a pregnancy with this condition.

Efficient drugs which are mostly preferred in the case of patients suffering from Polycystic Ovarian Syndrome are associated with several other disorders of various organs. PCOS requires first-line treatment for fertility. Drugs mostly suggested by the gynecologists for the fertility are Clomid (Clomiphene Citrate), and major drugs used in the case of blood glucose levels, diabetes, high blood pressure and high blood sugars. Several other drugs include various disorders regulated by the polycystic ovarian syndrome associated with major organs.

Bariatric surgery is a varied procedure which is mostly preferred for the patients who have obesity which was caused by excess fat deposition, this bariatric surgery is helpful to gain weight loss by reducing the size of the stomach with the gastric band. On consideration of women suffering from polycystic ovarian syndrome have several effects on their endocrine system, they experience the decreased ovarian volume and biomarkers of androgen excess levels. A specific study has been evaluate that women among 15% of women with PCOS 3% are observed who underwent the bariatric condition and observed for the pre-and postoperative weight loss and testosterone levels, BMI, Ovarian volume, fasting glucose and weight. outcomes of surgery suggests that a woman after bariatric surgery shows the resolution of the PCOS key conditions. Thereby the study results in the decreased in symptoms after  having bariatric surgery is encouraging, but such surgery is an extreme remedy and only appropriate for a few. A New method to decrease weight by taking bariatric surgery pill which is formulated using bioengneering methods.

Obstetrics is generally known as the branch that which deals with the study of pregnancy, childbirth and the postpartum period. based on the consequent changes in the surgical methods it is combined with the Gynecological department and it is fairly known as Obstetrics and Gynecology as a surgical field. This field of obstetrics is correlated with gynecological conditions like Polycystic ovarian syndrome (PCOS) which has a vast and varied relation with the women bearing pregnancy this PCOS consequence has an utmost effect on reproductive women. like elevates the impediments to a women to get pregnant there are several factors which include PCOS and causing an obstruction for the pregnancy, the major factor is excess insulin production in a circulatory system that which leads to the decrease in metabolism, Thereby causes dysfunction of pancreases. Women with PCOS can experience Gestational Diabetes, Preeclampsia. This leads to the maternal mortality the main causes of the maternal mortality are maternal bleeding maternal sepsis. There is no difference between symptoms and complication /Discomfort of pregnancy.

Postnatal depression  can be described as a type of mood disorder after childbirth which is well known as postpartum depression (PPD) which was regularly observed in women who are in relation with PCOS neither after giving birth to a child. The initiation or stimulation of (PPD) is unclear this condition is mainly including some characters which are probably in turn factors of causing PPD include mood disorders, irregular functioning of hormones, and behavioural changes can be a major factors of  PPD and similar consequent disorders which may cause the direct attack to the brain that which leads to neuronal disorders. this Postnatal /Postpartum depression is not limited to the mothers it also related to the father, this can happen in 1 in 10 men who had a negative/traumatic birth experience.

Effective study about the PCOS gives that it is caused by abnormal functioning of hormones and by the metabolic endocrinological disorder. There are more research works are process on investigationh to find the exact arise of the disorder and the partial way to sustain the further action worsened by the PCOS. The recent research work on plant product called Resveratrol- product obtained from the plant synthesis. Resveratrol has a property of Anti-oxidant most of the plants contain a type of phenol called phytoalenin (which was observed in plants like raspberries, grape & peanuts), obtained from plant tissues in response to invading fungus and stress and it also had a clinical feature of inflammatory properties it involves in the reduction of coronary heart diseases and it shows an effective work of fighting against cancer. Resveratrol drug is administrated into the systemic circulation of the women fighting with PCOS that may show an effective work against the hormonal imbalances. Evaluation can be done by taking the blood sample of the patient after 3 months of treatment for the determination of testosterone levels and other androgen hormone levels in the blood that which shows the development/ implementation of the syndrome. This defines the alteration of the implement. Taking natural diet like almonds, milk, and veggies can help to improve fertility and makes normal hormonal function.