Uma Shrivastava
Consultant Reproductive Endocrinologist, Infertility Centre, Nepal
Title: Combined clomiphene citrate-metformin versus letrozole-metformin in achieving pregnancy among women: Polycystic ovary syndrome
Biography
Uma Shrivastava is an Endocrinologist in Infertility and IVF Specialist. She is Founder and Executive Director of the Pioneer Institute in Infertility treatment in Infertility Centre, Nepal. She is also the Professor of Physiology and Vice-Principal at College of Biomedical Engineering and Applied Sciences. She has published more than 20 papers in journals,conference preceding and newspapers.
Abstract
Polycystic ovary syndrome is one of the most common causes of an ovulatory sub-fertility in women of reproductive age-group. Th e therapeutic procedure for women with polycystic ovary syndrome wanting to be pregnant is ovulation induction. Diff erent medicines have been used based on individual signs and symptoms as the most eff ective one is not clearly evident. Clomiphene Citrate and Letrozole are the most common drugs used alone or in combination with Metformin to achieve pregnancy in women with polycystic ovary syndrome. In this study, the effi cacy of combined Clomiphene Citrate-Metformin is compared with Letrozole- Metformin in achieving pregnancy among women with polycystic ovary syndrome. A retrospective study was performed among women with polycystic ovary syndrome attending Infertility Center, Kathmandu, Nepal from January 2013 to December 2015. Samples were randomly selected from the record of the treatment centre within the study duration. Total 146 cases with 73 each in clomiphene citrate-metformin group and letrozole-metformin group were entered into the analysis. Participants had received metformin in combination with either clomiphene citrate (100 mg) or letrozole (2.5 mg) from day 3 to 5 of their menstrual cycle. Odds ratio, with confi dence interval set at 95%, was calculated to compare the effi cacy between two groups. Th e pregnancy rate of Clomiphene citratemetformin was 54.79% and letrozole-metformin was 34.25%. Patients treated with clomiphene citrate-metformin were two times more likely to get pregnant [OR: 2.33, 95% CI: 1.19–4.54] than those treated with letrozole-metformin. Miscarriage rate was not found to be statistically signifi cant. Clomiphene citrate in combination with metformin is more likely to be eff ective in achieving pregnancy.