Saleem Ali Banihani
Jordan University of Science and Technology, Jordan
Title: Effect of Lansoprazole, a proton pump inhibitor, human semen quality parameters
Biography
Biography: Saleem Ali Banihani
Abstract
Lansoprazole is a commonly used acid reducer belongs to proton pump inhibitors family. It is used to relief various gastric illnesses such as esophageal reflux disease, ulcers, and Zollinger Ellison syndrome. In this study, as a supporting research of the post-marketing surveillance of lansoprazole, we revealed the in vitro effect of various concentrations of lansoprazole on
some seminal quality parameters such as sperm motility, sperm viability, and seminal nitric oxide concentration. Men with normal semen quality were recruited in this study. Lansoprazole at approximately 3.0 μg mL-1 concentration was found to significantly reduce progressive and total sperm motility, but it had no effect sperm viability or seminal nitric oxide level. Such
findings are of great importance for health care providers, mainly andrologists and urologists, and patients with poor semen quality, mainly patients with asthenozoospermia.