2^nd World Congress on Polycystic Ovarian Syndrome and Fertility December 09-10, 2019 Dubai, UAE

Eman I. Anwar completed her master’s degree Medical Basic Science in Pharmacology general grade Excellent, 2011 and Doctor degree in Clinical Pharmacology with GPA score: 3.642, August 2016. She is Pharmacovigilance & drug counseling center advisor at university hospital clinics Since June 2015 and Egyptian Association of Medical Basic Sciences (EAMBS) member since 2009. Her research interest is on Experimental pharmacology in oncology, endocrinology, Pharmacovigilance, Medical education and E-learning.

Ovarian hyper-stimulation syndrome (OHSS) is a severe iatrogenic potentially life-threatening complication of controlled ovarian stimulation. The primary risk factors for OHSS are young age, low body mass index, polycystic ovarian

syndrome (PCOS), and history of previous OHSS. Ovarian hypersecretion of vascular endothelial growth factor (VEGF) has been identified as a prime causative factor, playing a major role in the observed increases in angiogenesis and vascular permeability that are the pathophysiological components of OHSS. The pathogenesis of OHSS induced by either exogenous or endogenous human chorionic gonadotropin (hCG) triggers the syndrome. As hCG alone doesn’t exert a vascular activity, at least one angiogenic substance must be released from the ovary in response to gonadotropins. Subsequent studies have

focused on substances present in the follicular and ascitic fluid of hyper-stimulated women. Cytokines and growth factors (interleukins IL-2, IL-6, IL-8, IL-10, IL-18 and VEGF) are known to be implicated in the inflammatory processes associated with late follicular maturation, ovulation, corpus luteum function and embryo implantation. These factors were reported to mediate the vascular permeability in response to hCG. Several pharmacologic interventions have been proven to be effective in OHSS prevention, but randomized controlled trials have seldom compared multiple drugs’ effectiveness in preventing OHSS (primary outcome) and their influence on pregnancy rate as a secondary outcome. Five pharmacologic interventions were superior to placebo in decreasing OHSS incidence were cabergoline, metformin, aspirin, intravenous calcium, and hydroxyethyl starch. Glucocorticoid administration can presumably be linked to both beneficial and harmful effects on fertility

and pregnancy, depending on individual woman immune parameters and effects of glucocorticoids on immune cells in the peri-implantation endometrium. Immune cells including T cells, NK cells, dendritic cells and macrophages are all required for embryo implantation and robust placental development. Glucocorticoids affect the generation, recruitment, activation

phenotypes and function of different immune cells in various ways. The assumed possible protective effect of corticosteroids in OHSS is based on previous studies reporting inhibition of VEGF-gene expression, VEGF-induced vascular leakage and their current clinical use in the local management of diabetic retinopathy neovascularization and macular edema. The present study

compared the effects of hydrocortisone sodium succinate, methyl-prednisolone and dexamethasone systemic pre-treatment on induced severe OHSS model in female albino rats. Then the effect of methyl-prednisolone on severe OHSS prevention and endometrium immune cells infiltration were compared to cabergoline use alone and their combination.

Saher Rafiq , she is a student and doing Master in Clinical Psychology from University of Central Punjab Lahore. She worked in Fountain House which is a Mental Asylum for the duration of four months. She done her internship in Special Education amd Training Center and worked with the special children for four months. She also have gained experience of working with drug addicts as a psychologist in the addiction center of Lahore. Saher Rafiq previously done her graduation in Psychology from Government College University Lahore.

Women are often recognized and judged by their appearance, features and physique instead of their character, abilities, and intellect. While looking at the representation of women in popular media, one quickly gets picture of great looks and perfect body which is very difficult to attain, prompting feelings of deficiency or inadequacy. The aim of the current study is to explore the psychological problems faced by the women who are under treatment of polycystic ovarian syndrome (PCOS). PCOS is a purely medical and hormonal problem its symptoms include obesity, infertility, hair loss, acne, hirsutism

and menstrual irregularities but it had been shown to trigger psychological burden as well. The symptoms of PCOS lead women towards the fear of being negatively judged and distress regarding their appearance so it would impact social, dermatological as well as psychological aspects of women. Data was collected from public and private hospitals. Cross-sectional research design

was used by using purposive sampling. Sample size was n =180, calculated with the help of G-power analysis. The participants filled the demographic sheet along with following standardized scales; Derriford Appearance Scale (Carr, Moss & Harris,1991), Fear of Negative Evaluation Scale (Leary, 1983) and UCLA Loneliness Scale (Russell, 1996). The proposed statistical analysis includes descriptive statistics, Pearson product moment correlation, and analysis of variance (anova).

Fahimeh Golbabaei has completed her bachelor of midwifery at the age of 22 years and master’s degree at the age of 26 years both from School of Nursing and

Midwifery, Iran University of Medical Sciences. She worked in a hospital as a midwife for 2 years. Now, she is an access officer in “Family Health Association of Iran” which is an international NGO. She has done research in field of sexuality and taken many courses about sex therapy, couple therapy and psychotherapy in

university and other educational and research institutions.

Sexuality is an important aspect of life and sexual dysfunction is a common health problem among Iranian women. Prevalence of sexual dysfunction is very high in women with polycystic ovarian syndrome which has been most neglected in clinics. Studies have shown the effectiveness of sexual counseling based on PLISSIT model in improving sexual performance of women in various groups. However, the impact of this model has not been studied on women with PCO yet. This clinical trial study was conducted on 66 patients between the ages of 18-45 years. They were randomly allocated to two intervention (33 people) and control groups (33 people). In the intervention group, women received four sessions of weekly, one hour and face to face sexual counseling. Patients in the control group received routine care. The data gathering tools were a demographic questionnaire and Female sexual function Index (FSFI). The data were collected in three phases including before intervention, one month after the pre-test and follow up three months after the pre-test in both intervention and control groups. The sexual function score in two groups were compared by using Friedman, Mann Whitney U and Wilcoxon tests. Friedman test showed that the sexual function’s score and its domains in the intervention group were significantly higher than the control group (p<0/05), but there was no significant difference between the two groups in the lubrication score. The present study shows that PLISSIT model is effective in treatment of sexual dysfunction of women with polycystic ovarian syndrome. This model can be used in clinics in order to conduct sexual assessment and treatment of women with PCO.

Background: Gestational Diabetes Mellitus is a public health issue and one of the causes of maternal and fetal mortality and morbidity. Awareness of the condition among antenatal women will translate into adoption of a healthy lifestyle, better healthcare-seeking pattern, better self-care practice, which prevents acute complications, reduces the risk of long-term complications and promotes pregnancy outcome.

 

Objectives: The study was aimed to assess the knowledge and self-care practice among the antenatal women with Gestational Diabetes Mellitus.

 

Method: A descriptive cross-sectional study was conducted among 60 antenatal women who had GDM attending antenatal ward and OPD of BPKIHS by using purposive sampling method. Data was collected by interview method and analyzed using descriptive and interferential statistics at level of significance 0.05.

 

Result: The study findings revealed that 36.7% of the respondents were in the age group of less than 25 years and the mean age was 28.10 with standard deviation of 5.251. Among the respondents, 64.2% had completed secondary level education. The overall knowledge regarding GDM was good in 33.3%, average in 40% and poor 26.7%, whereas regarding self-care practice only 11.7% had good practice, majority of 80% had average and 8.3% had poor practice. And the relationship between knowledge, and practice was found statistically significant.

 

Conclusion: Most of the respondents had good knowledge regarding GDM but most of them did not have positive self-care

practice though there is positive relationship that reflects the need of further support.

Uzma Ilyas, Senior Lecturer at University of Central Punjab, Lahore. She have experience of both academia and clinical practice of last almost 11 years. She served at different designations including Clinical Psychologist at SOS Children’s Village, Lahore. She also served as Head of Department Psychology, Garrison University, Lahore. Currently, she is polishing and focusing the gaps in research in Pakistani societies. My main area of interest includes female population along with cross cultural aspects among professional and genders.

The role of female as wife is considered crucial in child-bearing and extending family and any delays in conception attributed towards non-productive and stagnant. Infertility is the worldwide issue, it has profound impact on women's

mental health and on the person as a whole. For many couples, infertility is as much an emotional and spiritual crisis as it is a physical challenge. The role of spouse and uncertainity in relationship is aftermath that follows infertility and need to be addressed for comprehending correlate of infertility. Physical, emotional, sexual and spiritual aspects of one's life are all affected by this disease of the reproductive system. Women with infertility felt anxious and depressed, along with low selfesteem, stigma, and depression as childless women. (Harvard& Mental Health, 2009).Data was collected from public and

private hospital from the women with primary infertility. Cross-sectional research design was used by employing purposive sampling. Sample size was n =200, calculated with the help of G-power analysis. The participants filled the demographic sheet along with following standardized scales; Relational Uncertainty Scale (Knobloch, 2007), Multidimensional Scale of Perceived

Social Support(Zimet,1988), Coping Styles Scale(Zaman,2015), Relational Turbulence Scale(Knobloch, 2007) and Symptom Checklist-R (Dawood, Rahman, Mansoor, Rehman& Ali, 2009). The proposed statistical analysis includes descriptive statistics, Pearson product moment correlation, and analysis of regression.