Polycystic Ovarian Syndrome and Fertility

Polycystic Ovary Syndrome (PCOS) is one of the most common endocrinopathy affecting women. It affects around 80% of anovulatory infertile cases. It has an unknown etiology and is recognized as a heterogeneous disorder that results in overproduction of androgens, primarily from the ovary, and is associated with insulin resistance. Patients with PCOS represent a challenge for reproductive medicine. They present with many complications and challenges for IVF treatment. The use of a calculated low-dose stimulation strategy with step-up according to ovarian response may help in thoughtful management of these patients. Careful selection of FSH dose may help in mitigating the risk of OHSS. The choice of the starting dose of FSH has to be calculated by patient’s basal AMH level, AFC, age, BMI and PCOS diagnosis.