6^th Annual Congress on Polycystic Ovarian Syndrome and Fertility December 07-08, 2023 London, UK

Anovulation can be caused by Polycystic ovarian syndrome, which is caused by factors such as an excess production of androgens known as male hormones, insulin levels, and inflammation.

Anovulation is the inability to release an oocyte as a result of irregular menstrual cycles. This impediment caused by irregular menstruation can cause menopause to a woman under control and women suffering from PCOS. If this process of disruption in ovulation continues, it is difficult for women to become pregnant, which may lead to complications in getting pregnant and most of the hormones become unbalanced, making it difficult to carry a baby.

Endometrial cancer is a type of cancer that begins in the ovaries, which are the size of an almond and are involved in egg production. Endometrial cancer develops from the endometrial layer (the uterine/womb lining). This is caused by abnormal cell growth, which has the ability to spread and invade normal cells and the functioning of other systems. It is also known as uterine cancer at times. Endometrioid carcinomas is the name given to this type of cancer. The main symptom of this cancer is vaginal bleeding that is not related to the menstrual cycle, and endometrial cancer usually develops after menopause. We can also speculate that the cancer is caused by an overexposure of the uterine walls to oestrogen levels. When it comes to the cause of this cancer, 2-5 percent of cases are linked to genes inherited from parents. Prolonged menstrual cycles of more than 35 days may progress to a severe condition that leads to endometriosis.

Women suffering from polycystic ovarian syndrome have side effects such as diabetes, obesity, obstructive sleep apnea (OSA), heart disease, mood disorders, and endometrial cancer. The major function in blood varies is that insulin resistance develops, resulting in an increase in blood glucose levels in the body. This can be determined by conducting insulin level blood tests. Excess blood glucose results in the diagnosis of TYPE-2 diabetes in patients. PCOS is the most common hormonal disorder in women of childbearing age and can cause infertility issues, as well as cause weight loss or gain in women. Women who are more sensitive to insulin or who have insulin resistance due to a hormonal imbalance are more likely to be obese or overweight, putting the patient at a higher risk of heart disease, sleep apnea, and uterine cancer.

Obstructive sleep apnea is associated with metabolic disorders of the insulin that are caused by glucose intolerance in the bloodstream, the main symptom of OSA is restricted sleep entirely during the night times, the early stages of this OSA is snoring at night times and having irregular sleep, and this can cause effects of the quality of sleep towards the patient associated with PCOS. No two women with PCOS will experience the same symptoms. The condition of women with PCOS has several disorders that occur as a result of the polycystic ovarian syndrome. PCOS is associated with emotional and mental conditions such as anxiety, depression, difficulty concentrating, fatigue, mood swings, and chronic stress. Zinc is essential for building immunity in women suffering from PCOS, which causes infertility, as well as for improving fertility.

In vitro fertilisation is a medical treatment or assisted reproductive technology used to help a woman conceive. Invitro fertilisation took a step toward monitoring and stimulating women's ovulatory processes by extracting sperm from the father and egg from the mother and allowing them to combine and fertilise to form an embryo. Once the embryo has been formed, it will be implanted into the mother's uterus. This implantation allows women to conceive more easily because the eggs have been fertilised by sperms outside of the normal biological process. It is also referred to as a type of assisted reproductive technology that is primarily used to treat infertility.

High levels of male sex hormones (Androgens) and irregularity in the production of sugar levels in the bloodstream cause insulin resistance, which can have a negative impact on the menstrual cycle and prevent the release of an egg on a regular basis, or even stop completely or irregularly. This condition makes it more difficult for women with polycystic ovarian syndrome to have an easy pregnancy and makes it more difficult for those women to conceive, which can sometimes lead to miscarriage. Women who meet certain criteria may also experience reduced fertility or subfertility, necessitating additional medical attention. Sixty percent of PCOS women become pregnant without medical assistance.

Laparoscopy is a sophisticated surgical procedure that involves inserting a fiber-optic instrument through the abdominal wall into the abdomen to provide a clear internal view of organs. Laparoscopy is one of the most advanced techniques used to treat or diagnose fertility complications or factors that cause fertility problems in patients suffering from infertility. Laparoscopy can be used on patients who have previously been diagnosed with infertility using ultrasound, ovarian reserve for females, and Semen Analysis for men. Laparoscopy is an in-depth examination of the uterus, ovaries, fallopian tubes, and pelvis of women experiencing fertility complications, with the goal of determining any abnormalities that may be affecting the women's fertility or ability to conceive. If a complication or abnormality is discovered during laparoscopy, additional instruments can be inserted through a tiny incision to aid in the diagnosis of infertility issues such as poor ovarian reserve or ovarian failure.

Fertilization is the process of combining male gamete and female gamete, which results in the formation of zygote in 10% of males suffering from infertility with Spermatogenesis disorder due to drastic changes in their lifestyle, surroundings, or environmental factors and Hormonal imbalances most of the couple, i.e., 17.2% of couples in 30% are not expected to have a child There are numerous reasons to consider what is causing infertility in either the male or female of that particular couple. Various modern inventive techniques for becoming fertile have been introduced. Because these methods are based on in vitro steps or procedures to improve sperm quality in order to overcome the natural barrier of fertilisation. Techniques include a variety of processes that each have their own specific indications.

Immune infertility has become a serious health issue, affecting one in every five women under normal circumstances; additionally, women with polycystic ovarian syndrome are becoming more common. Semen, also known as the composite fluid that contains sperm, cellular vesicles, and other cell components, may be a cause of sensitization of the female genital tract. Natural tolerance of the female reproductive tract caused by immune rejection of male sperm, which is a predisposing factor leading to a local or systemic response. Iso-immunization has also been linked to infertility. There are numerous specific components of the regenerative system that do not exist in other body systems, many of which are immunogenic efforts.

Most women with Polycystic Ovarian Syndrome have a direct effect on nearby or interconnected major organs, which is usually caused by hyperinsulinemia; this hyperinsulinemia will negatively affect major organs. As the frequency of PCOS in women increases, it causes various disadvantages to the major functioning organs due to increased levels of Androgen Hormones in the body, influencing the higher risk factor to the patient and leading to the patient medical profiles with various diseases that cause side effects to the other organs in the system. Women with this condition may have severe feeding complications after giving birth due to low estrogen levels, which is the main factor that obstructs mammary tissue formation by producing less estrogen. Some of the major causes of Autism in a child born to a mother with Polycystic Ovarian Syndrome. Women who are predisposed to PCOS may have several neuronal defects that can lead to psychiatric disorders during the prenatal or postnatal period. These psychiatric impediments in PCOS women are frequently associated with menstrual cycle irregularities.

Fertility of women affected by the hormonal and endocrine-metabolic disorder known as polycystic ovarian syndrome is heterogeneous hormonal imbalance is the condition in which hirsutism, hyperandrogenism, and various other conditions primarily show an effect on the female reproductive system, resulting in infertile nature of women regenerative hormones. PCOS has no course and can be treated in its early stages, with symptoms such as hirsutism, acne, obesity, and others requiring specific treatment. Fertility is indigenously linked to subsequent lifestyle changes such as exercising and maintaining dietary subsidies and medication to alleviate the problem of infertility. Though achieving fertility in such PCOS-affected women is a little more difficult, there are some medications and treatments that show varying results.

Fertility can be defined as a woman's hormonal cycles that determine when she can achieve pregnancy; fertility is the ability of a woman to produce an offspring. Fertility declines in both men and women as they get older. Women generally lose fertility at a high rate between the ages of 45 and 50, as measured by fecundity (Potential for reproduction). Infertility is defined as a woman's inability to produce or conceive a child after 12 months or having difficulty carrying a pregnancy to term. There are no definite factors to evaluate the cause of infertility; it is dependent on hormonal imbalances; however, the main symptoms of infertility include inability to conceive, irregular menstrual cycles, hormonal complications such as hair growth, and sexual function. Among the causes of infertility are

Efficient drugs, which are mostly preferred in the case of patients suffering from Polycystic Ovarian Syndrome, are linked to a number of other organ disorders. PCOS necessitates first-line fertility treatment. Clomid (Clomiphene Citrate) and major drugs used in the case of blood glucose levels, diabetes, high blood pressure, and high blood sugars are the most commonly recommended by gynaecologists for fertility. Several other drugs are used to treat disorders caused by the polycystic ovarian syndrome that affect major organs.

The majority of patients who undergo bariatric surgery have obesity that was brought on by excess fat deposition. By using a gastric band to reduce the size of the stomach, this operation helps patients lose weight.

Women with polycystic ovarian syndrome experience decreased ovarian volume and elevated levels of biomarkers for androgen excess, among other consequences on their endocrine system. A specific study has evaluated the pre- and postoperative weight reduction, testosterone levels, BMI, ovarian volume, fasting glucose, and weight of 3 percent of the 15% of women with PCOS who underwent the bariatric procedure. Surgery results imply that a lady who has had bariatric surgery will have her PCOS's main symptoms resolved. The study's findings that symptoms lessened following bariatric surgery are therefore positive, but this kind of surgery is a severe cure and is only suitable for a select few. a brand-new way to lose weight involves taking a bariatric surgery pill that was made utilising bioengineering techniques.

The field of medicine known as obstetrics focuses on the study of pregnancy, childbirth, and the postpartum period. Based on the ensuing modifications in surgical techniques, it is integrated with the gynaecological division and is generally known as the surgical specialty of obstetrics and gynaecology. Obstetrics has a connection to gynaecological diseases like polycystic ovarian syndrome (PCOS), which affects pregnant women in a variety of ways. PCOS's effects are particularly severe in women who are trying to get pregnant. In addition to PCOS and other variables that might make it difficult for a woman to become pregnant, the main obstacle is excessive insulin production in the circulatory system, which causes a drop in metabolism and, as a result, pancreatic dysfunction. Preeclampsia and gestational diabetes can affect women with PCOS. This results in maternal death, which has two main causes: maternal haemorrhage and maternal sepsis. There is no distinction between symptoms and pregnancy complications or discomfort.

Postpartum depression (PPD), often referred to as postnatal depression, is a type of mood illness that develops after childbirth and is frequently seen in women who have PCOS or who have recently given birth to a child. The cause or origin of PPD is unknown, but it is thought to be primarily caused by a number of characteristics, such as mood disorders, hormonal imbalances, and behavioural changes. PPD and similar subsequent disorders may also be caused by a direct attack on the brain, which can result in neuronal disorders. One in ten males who experienced a difficult or traumatic birth can develop postnatal Or postpartum depression, which is not just tied to the mothers.

Effective research on PCOS indicates that the disorder is brought on by metabolic endocrinological dysfunction and improper hormone function. More research is being done to determine the precise cause of the disorder and a partial solution to support any subsequent PCOS-related actions that get worse. Recent studies have focused on a plant substance called resveratrol, which is produced through plant synthesis. The majority of plants, including those that grow raspberries, grapes, and peanuts, contain a type of phenol called phytoalenin, which is obtained from plant tissues in response to stress and invading fungi. Resveratrol also has anti-inflammatory properties, which it uses to lower the risk of coronary heart disease and to fight cancer effectively. Women with PCOS are administered a resveratrol medication into their systemic circulation, which may function effectively against hormonal abnormalities. After three months of treatment, the patient's blood can be drawn for analysis in order to determine the levels of testosterone and other androgen hormones that indicate the emergence or manifestation of the syndrome. This describes how the tool has changed. Including natural foods in your diet, such as almonds, milk, and vegetables, can assist to increase fertility and promote healthy hormonal function.