4^th World PCOS Congress November 22-23, 2021 Rome, Italy

Obesity is a common finding in women with PCOS. Between 40–80% of women with this condition are accounted for to be overweight or fat. Familial collection of PCOS unequivocally bolsters a hereditary helplessness to this issue. Bariatric medical procedure can be effective in accomplishing critical weight reduction, rebuilding of the hypothalamic pituitary pivot, decrease of cardiovascular danger and even in improving pregnancy results. Eventually, bariatric medical procedure ought to be viewed as a feature of the therapy in PCOS women.

High levels of male sex hormones (Androgens) and irregularity in the production of sugar levels in the bloodstream causes insulin resistance can adversely affect menstrual cycle and prevent the release of an egg on a regular basis and can even stop completely or irregularly. This condition makes more difficult for women suffering from polycystic ovarian syndrome to have their easy pregnancy and it is more difficult for those women to conceive, sometimes it can lead to miscarriage. Women in some criteria may also experience reduced fertility or sub-fertility which requires further medical assistance. 60% of women suffering from PCOS become pregnant without any medical assistance.

• Monitoring ovulation
• Surgery for improving fertility
• Assisted reproductive technology
• Various medications
• Weight management

Laparoscopy is an advanced surgical procedure in which insertion of a fiber- optic instrument in the abdomen through the abdominal wall to have a clear internal view of organs. Laparoscopy is one of the most advanced techniques referred to the patients suffering from infertility, it is used to treat or diagnose the fertility complications or factors causing fertility problems. Laparoscopy can be performed to the patients who are previously known to a basic evaluation of infertility include ultrasound, ovarian reserve for female and Semen Analysis for men. Laparoscopy involves in the in-depth examination of the uterus, ovaries, fallopian tubes and pelvis of women having fertility complications which results out to know the abnormalities that might involve women fertility or inability to conceive. If this detects the complication or abnormalities during laparoscopy additional instruments can be placed through a tiny incision which can involve in the diagnosis of infertility problems like Poor ovarian Reserve or Ovarian Failure.

• Blocked fallopian tubes
• Uterine Abnormalities
• Pelvic Adhesions
• Abnormal Cervical Mucous
• Male Infertility Complications

Fertilization is the process of combining male gamete and female gamete which results in the formation of zygote in 10% of male suffering from infertility with Spermatogenesis disorder due to drastic alteration in their lifestyle, surroundings or environmental factors and Hormonal imbalances most of the couple i.e., 17.2% couple in 30% are not supposed to have a child. There are numerous reasons to evaluate that causing infertility either in male or female of that certain couple. To get fertile various modern inventive techniques has been introduced. Since these methods are based on the steps or procedure of in vitro improvement in Semen quality to over the natural barrier of fertilization. Techniques include various process on their own specific indications.

• Gamete intrafallopian transfer (GIFT)
• Hormonal testing’s
• Microsurgical aspiration
• Zona pellucida drilling
• Genetic testing
• Intracytoplasmic injection of sperm (ICSI)

Immune infertility has become a severe health issue involving 1 in 5 women under normal conditions; moreover, women with the polycystic ovarian syndrome has become very frequent. Semen that is known as the composite fluid which contains sperm, cellular vesicles, and other cell components, this semen could be a reason for sensitization of female genital tract. Natural tolerance of female regenerative tract by the immune rejection of male semen which is a prior factor leading to local or systemic response. Iso-immunization is also associated with infertility. Numerous specific components of the regenerative system which do not represent in other body systems those many of are immunogenic efforts. The major advantage involved in the immunological approach of fertility is very effective or potential for women who are infrequent administration by a specialist's trained people who could deliver antifertility services.

• Seminal fluid in female immune infertility
• Mucosal immunity of the female genital tract
• Ovulation Induction
• Hormonal Regulation

Most of the women suffering from Polycystic Ovarian Syndrome have a direct effect on nearer or interrelated major organs which is usually caused by Hyperinsulinemia, this hyperinsulinemia will adversely affect's major organs. in order of increase in regular alterations of PCOS in women it leads to various disadvantages to the major functioning organs due to increased levels of Androgen Hormones in the body that which influencing the higher risk factor to the patient and leads patient to the severe condition in which it leads to the patient medical profiles with various diseases that cause side effects to the other organs in the system. Women at this condition may experience severe complications in feeding babies after giving birth due to decreased levels of estrogen that which is the major factor which obstructs by making less estrogen into mammary tissue building. Some of the major factors that evolve Autism in a child of a mother suffering from Polycystic Ovarian Syndrome. Women who are prone to PCOS may have several neuronal defects which can cause psychiatric disorders in the stage of pre or postnatal span. These psychiatric impediments in women with PCOS are often related to irregularities in menstrual cycles.

• Autoimmune disease
• Endo-neurological diseases
• Uro-gynecologic disorders
• Heart diseases

Fertility of women adversely affected by the hormonal and endocrine-metabolic disorder called polycystic ovarian syndrome is heterogeneous hormonal imbalance is the condition in which characterized by the hirsutism, hyperandrogenism and various other conditions primarily show an effect on the female reproductive system that in turn causes infertile nature of women regenerative hormones. PCOS has no course it can be treated in early condition and symptoms like hirsutism, acne, obesity and other involved in specific treatment. Fertility is indigenously related to subsequent alterations in lifestyle changes like exercising and maintaining the dietary subsidies and medication to improve the problem of infertility Thinking to achieve fertility of such women suffering from PCOS is little more difficult there are some medications and treatments which show varied results.

• Fertility medications
• Birth control pills
• Progestin Therapy
• Home remedies
• Cyst aspiration 
• Ovarian drilling
• Hysterectomy

Fertility can be defined as the women have hormonal cycles that which determine when they can achieve pregnancy, the capability of women to produce an offspring called fertility. Fertility declines in order with age progression in both men and women. Woman generally have a high rate of losing fertility around the age of 45-50. which can be measured through fecundity (Potential for reproduction). Infertility primarily refers to the inability of women to produce or conceive a child after 12 months or feeling difficulty to get a pregnancy to full term. There are no such definite factors to evaluate the cause of infertility it depends on the hormonal imbalances but the main symptom of infertility include, inability to get pregnant, irregular menstrual cycles, hormonal complications such as hair growth, sexual function. Factors causing infertility include

• Age
• History of sexually transmitted infection
• Irregular periods
• Body weight and Exercise
• Tobacco and alcohol use

Effective study about the PCOS gives that it is caused by abnormal functioning of hormones and by the metabolic endocrinological disorder. There are more research works are process on the investigation to find the exact arises of the disorder and the partial way to sustain the further action worsened by the PCOS. The recent research work on plant product called Resveratrol- product obtained from the plant synthesis. Resveratrol has a property of Anti-oxidant most of the plants contain a type of phenol called phytoalenin (which was observed in plants like raspberries, grape & peanuts), obtained from plant tissues in response to invading fungus and stress and it also had a clinical feature of inflammatory properties it involves in the reduction of coronary heart diseases and it shows an effective work of fighting against cancer. Resveratrol drug is administrated into the systemic circulation of the women fighting with PCOS that may show an effective work against the hormonal imbalances. Evaluation can be done by taking the blood sample of the patient after 3 months of treatment for the determination of testosterone levels and other androgen hormone levels in the blood that which shows the development/ implementation of the syndrome. This defines the alteration of the implement. Taking natural diet like almonds, milk, and veggies can help to improve fertility and makes normal hormonal function.